PNC-27

Signalling & repair

p53-derived chimeric peptide, researched in vitro in HDM-2 interaction and in cell membrane integrity.

Purity	>98%
Molecular formula	C₁₈₈H₂₉₃N₅₃O₄₄S
Molecular weight	4032.00 Da
CAS number	1159861-00-3

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10 mg 129.95€

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It arrives lyophilized: you need bacteriostatic water to reconstitute it.

Bacteriostatic water · 10 ml 9.95 €

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For scientific research only. This product is not approved for human, veterinary or diagnostic use. By purchasing it you confirm that you will use it exclusively for laboratory research purposes.

Research background

PNC-27 is a 32-amino-acid synthetic peptide made of two parts: residues 12-26 of p53 (PPLSQETFSDLWKLL), which form the domain through which p53 binds its regulator HDM-2, and a seventeen-amino-acid segment of the Antennapedia protein, described as a membrane-penetrating sequence.

The reference work is laboratory-based (Sarafraz-Yazdi et al., PNAS 2010). The authors describe HDM-2 in the membranes of several tumour cell lines but not in those of several untransformed lines, and observe that the peptide binds this membrane HDM-2 and causes cell lysis. Other work studies it through theoretical models of its structure. None of the PubMed-indexed articles on PNC-27 is classified as a clinical trial.

Reconstitution and handling

Work on a clean surface and disinfect the vial stopper with an alcohol wipe before piercing it.
Add the bacteriostatic water slowly, letting it run down the inner wall of the vial rather than landing on the powder.
Do not shake. Swirl the vial gently until the lyophilized powder has fully dissolved: vigorous agitation degrades the peptide.
The solution should come out clear. If it turns cloudy or shows suspended particles, do not use it.