Sermorelin

Growth hormone secretagogues

Fragment 1-29 of GHRH, the shortest that retains its activity, researched in GHRH receptor signalling and pulsatile secretion.

Purity	≥99%
Molecular formula	C₁₄₉H₂₄₆N₄₄O₄₂S
Molecular weight	3357.90 Da
CAS number	86168-78-7

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10 mg 89.95€

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It arrives lyophilized: you need bacteriostatic water to reconstitute it.

Bacteriostatic water · 10 ml 9.95 €

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For scientific research only. This product is not approved for human, veterinary or diagnostic use. By purchasing it you confirm that you will use it exclusively for laboratory research purposes.

Research background

Human GHRH has 44 amino acids, but the activity at its receptor resides entirely in the first 29: that finding is what defines Sermorelin and what made it the reference analogue of the group. Everything that came later — Tesamorelin, both CJC-1295 — starts from this same fragment and adds modifications to it to resist degradation.

And there lies its other interesting half. Unmodified, the 1-29 is degraded within minutes by dipeptidyl peptidase IV, which cuts at the N-terminal end. It is a short half-life compared with that of its derivatives, and that is why the literature uses it as a probe for a punctual stimulus of the axis: it allows an isolated pituitary response to be studied rather than a sustained exposure.

It should not be confused with CJC-1295 no-DAC, which the sector also sells as "Mod GRF 1-29": that is this same fragment with four amino acid substitutions, not the original sequence. They share an origin, but not a CAS number or a formula, and in this catalogue they are two separate products.

Read the scientific page on Sermorelin

Reconstitution and handling

Work on a clean surface and disinfect the vial stopper with an alcohol wipe before piercing it.
Add the bacteriostatic water slowly, letting it run down the inner wall of the vial rather than landing on the powder.
Do not shake. Swirl the vial gently until the lyophilized powder has fully dissolved: vigorous agitation degrades the peptide.
The solution should come out clear. If it turns cloudy or shows suspended particles, do not use it.